A Ethnopharmacological relevance:
Copaifera langsdorffii Desf. (copaiba), Hymenaea courbaril L. (jatobá), and Mauritia
flexuosa L. (buriti) are traditionally used in Brazilian folk medicine for wound healing
and treatment of inflammatory conditions, processes closely associated with
angiogenesis.
Aim of the study:
This study aimed to evaluate the pro-angiogenic potential of oils obtained from these
species using the chick chorioallantoic membrane (CAM) model.
Materials and methods:
A total of 36 fertilized eggs were distributed into experimental groups, including
negative control (distilled water), positive control (Regederm®), inhibitory control
(dexamethasone), and treatment groups. Angiogenesis was quantitatively assessed by
morphometric analysis using ImageJ and AngioTool software, considering total
vascular length, number of junctions, and endpoints. Statistical analysis was performed
using the Kruskal–Wallis test (p < 0.05) followed by Dunn’s post hoc test and
Spearman’s correlation.
Results:
Copaiba and jatobá oils significantly increased vascular length, number of junctions,
and endpoints compared to the negative control (p < 0.05), indicating a pronounced
pro-angiogenic effect. In contrast, buriti oil did not show significant activity. A strong
positive correlation was observed between the number of junctions and endpoints (ρ =
0.83; p = 0.041), suggesting coordinated stimulation of vascular sprouting and network
branching. The observed effects may be associated with the terpenoid-rich
composition of copaiba and jatobá oils, in contrast to the fatty acid-dominant profile of
buriti oil.
Conclusion:
Copaiba and jatobá oils exhibit significant pro-angiogenic activity in the CAM model,
supporting their traditional use in wound healing and highlighting their potential as
natural sources of bioactive compounds for applications in tissue regeneration and
regenerative medicine
MARTINS, N. J. N.; MORAES, E. I. M.. PRO-ANGIOGENIC POTENTIAL OF CERRADO-DERIVED OILS: AN IN VIVO STUDY USING THE CHICK CHORIOALLANTOIC MEMBRANE MODEL. UNIRG - UNIVERSIDADE DE GURUPI - 2026. Disponível em https://repositorio.unirg.edu.br/documento/469. Acesso em 23/10/2026.